Mutalipov A., Karimjonov H., Zaynabiddinov А., Usmanov P., Omonturdiev S., Rakhimov R. – DETERMINATION OF THE RELAXANT EFFECT OF SOME HYDROLYZABLE TANNINS ISOLATED FROM THE PLANT SPECIES E. SANESCENS (L.)
DETERMINATION OF THE RELAXANT EFFECT OF SOME HYDROLYZABLE TANNINS ISOLATED FROM THE PLANT SPECIES E. SANESCENS (L.)
Mutalipov A.
Andijan State University
Karimjonov H.
Andijan State University
Zaynabiddinov А.
Andijan Institute of Economics and Construction
Usmanov P.
Head of the Cell Biophysics Laboratory of the Institute of Biophysics and Biochemistry under UzMU
Omonturdiev S.
Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Rakhimov R.
Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Abstract
In studies, 2,3-di-O-galloyl-β-D-glucose and 1,2,3,4-tetra-O-galloyl-β-D-glucose The vasorelaxant effect of – hydrolyzable tannins on the contractile activity of the rat aortic blood vessel preparation was studied depending on their structure. In our experiments, it was determined that the vasorelaxant effect of hydrolyzable tannins depends on their structure and applied doses, and it was determined that it is related to the blockade of Ca2+ channels of vascular smooth muscle cells and sarcoplasmic reticulum.
Keywords: Tannin, blood vessel, relaxant effect, aorta, muscle, Ca2+-channel, dose, relaxation.
