{"id":1531,"date":"2023-11-13T12:09:30","date_gmt":"2023-11-13T09:09:30","guid":{"rendered":"https:\/\/nor-ijournal.com\/?p=1531"},"modified":"2023-11-21T19:01:57","modified_gmt":"2023-11-21T16:01:57","slug":"120-9","status":"publish","type":"post","link":"https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-9\/","title":{"rendered":"Lazarov G., Mladenov V. – INCREASED VALUES OF THE E2\/T RATIO, TOTAL PROSTATE VOLUME AND LOWER URINARY TRACT SYMPTOMS IN MEN AGED 37 TO 45 YEARS. CROSS-SECTIONAL PILOT CLINICAL STUDY"},"content":{"rendered":"
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INCREASED VALUES OF THE E2\/T RATIO, TOTAL PROSTATE VOLUME AND LOWER URINARY TRACT SYMPTOMS IN MEN AGED 37 TO 45 YEARS. CROSS-SECTIONAL PILOT CLINICAL STUDY<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Lazarov G.
<\/strong>MD(corresponding author): Department of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 73 Tzarigradsko shose Blvd., 1113 Sofia; Hospital in Obstetrics and Gynecology<\/em> “St. Sofia”, \u0410ndrological Office, 2 Mihalaki Tashev Str<\/em>., 1330 Sofia, Bulgaria
<\/em>ORCID ID:\u00a0 <\/em>https:\/\/orcid.org\/0000-0001-7373-4302<\/em><\/a><\/p>

Mladenov V.
<\/strong>Clinic<\/em> of Urology, <\/em>Medical University, <\/em>UMBAL Alexandrovska, <\/em>\u201cSv G. Sofijski\u201d Str. <\/em>\u21161, <\/em>1431 <\/em>Sofia, Bulgaria\u00b2
<\/em>ORCID iD:\u00a0\u00a0<\/em>https:\/\/orcid.org\/0000-0002-7409-8085<\/em><\/a><\/p>

Abstract
<\/strong>Introduction
<\/strong>We were looking for a relationship between total prostate volume, lower urinary tract symptoms and increased values of the E2\/T ratio <\/strong>in young men.
Materials and Methods
<\/strong>We have examined 73 men aged 37 to 45 with lower urinary tract symptoms and increased values of the <\/strong>E2\/T ratio. We use an appropriate questionnaire, diagnostic ultrasound and uroflowmetry as methods to evaluate total prostate volume, residual urine, and the maximum urinary flow. We selected a control group of 20 men of similar age without lower urinary tract symptoms.
Results
<\/strong>In the patients with lower urinary tract symptoms, we observed, though within the reference limits, significantly decrease in the level of serum testosterone below average values for a prolonged period and increased values of the E2 and E2\/T ratio, compared to those of the control group (p<0.001). We found significant differences between the studied patients and those of the control group in a number of points in the answers to the questions (p<0.001), E2\/T ratio (p<0.001), total prostate volume (p<0.001) and the maximum urinary flow (p<0.001).
Conclusion
<\/strong>Our study shows that some young men with lower urinary tract symptoms have some reduction in normal testosterone secretion and an increase in estradiol\/testosterone ratio values that are significantly different from the same values in their peers without lower urinary tract symptoms. According to our results, overweight and obesity are important, but not \u0430 necessary condition for the occurrence of lower urinary tract symptoms and the increase of total prostate volume.<\/p>

\u00a0<\/strong>Keywords:<\/strong> LUTS,<\/strong> prostate volume, \u04152\/\u0422 ratio, young men<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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