{"id":1541,"date":"2023-11-13T12:11:09","date_gmt":"2023-11-13T09:11:09","guid":{"rendered":"https:\/\/nor-ijournal.com\/?p=1541"},"modified":"2023-11-21T19:08:25","modified_gmt":"2023-11-21T16:08:25","slug":"120-11","status":"publish","type":"post","link":"https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/","title":{"rendered":"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. &#8211; GENE THERAPY IN MUCOVISCIDOSIS"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"1541\" class=\"elementor elementor-1541\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t<div class=\"has_eae_slider elementor-element elementor-element-174423c e-flex e-con-boxed jltma-glass-effect-no wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-eae-slider=\"19881\" data-id=\"174423c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"has_eae_slider elementor-element elementor-element-e289846 e-con-full e-flex jltma-glass-effect-no wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-eae-slider=\"80340\" data-id=\"e289846\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b5a0a35 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"b5a0a35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">GENE THERAPY IN MUCOVISCIDOSIS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-863f119 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"863f119\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: right;\"><strong>Novruzova M.<br \/><\/strong><em>Doctor of Philosophy in Biology, associate professor<\/em><\/p><p style=\"text-align: right;\"><strong>Talibova J.<br \/><\/strong><em>Doctor of Philosophy in Medicine, senior lecturer<\/em><\/p><p style=\"text-align: right;\"><strong>Gasimova M.<br \/><\/strong><em>assistant<\/em><\/p><p style=\"text-align: right;\"><strong>Muradova S.<br \/><\/strong><em>Doctor of Philosophy in Biology, senior lecturer<\/em><\/p><p style=\"text-align: right;\"><strong>Suleymanova T.<br \/><\/strong><em>Doctor of Philosophy in Biology, senior lecturer<br \/><\/em><em>Department of Medical Microbiology and Immunology, Azerbaijan Medical University<br \/><\/em><em>Azerbaijan, Baku<\/em><\/p><p><strong>Abstract<br \/><\/strong>The article describes the advantage of the CRISPR-Cas 9 gene editing method for the treatment of cystic fibrosis. This method uses plasmids that contain CRISPR-Cas 9 components in the form of DNA, a nuclease expression cassette, and a bay RNA cassette. The advantage of the method is that no matter how CRISPR-Cas 9 is delivered to the cell, it immediately removes some gene fragment or replaces it. And this change remains forever in the cell, and in the descendant of this cell, we hope that this method of treatment will reduce the number of deaths in cystic fibrosis.<\/p><p><strong>Keywords:<\/strong> cystic fibrosis, CRISPR-CAS-9, gene fragment, cell, mitochondria.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-206ce67 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-pdfjs_viewer\" data-id=\"206ce67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pdfjs_viewer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<iframe data-src=\"https:\/\/nor-ijournal.com\/wp-content\/plugins\/pdf-viewer-for-elementor\/assets\/pdfjs\/web\/viewer.html?file=https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-49-53.pdf&amp;embedded=true\" style=\"display: block; margin-left: auto; margin-right: auto; width: 770px; height: 1045px;\" frameborder=\"1\" marginheight=\"0px\" marginwidth=\"0px\" allowfullscreen src=\"about:blank\" class=\"lazyload\" data-load-mode=\"0\"><\/iframe>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"has_eae_slider elementor-element elementor-element-6ecc5fe e-con-full e-flex jltma-glass-effect-no wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-eae-slider=\"93628\" data-id=\"6ecc5fe\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d0eb8f5 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"d0eb8f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"723\" height=\"1024\" src=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg\" class=\"attachment-large size-large wp-image-1422\" alt=\"NJD_120\" srcset=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg 723w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-212x300.jpg 212w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-768x1088.jpg 768w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-1084x1536.jpg 1084w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-1445x2048.jpg 1445w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-8x12.jpg 8w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-scaled.jpg 1807w\" sizes=\"(max-width: 723px) 100vw, 723px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c17264 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-ha-creative-button happy-addon ha-creative-button\" data-id=\"9c17264\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-creative-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-magnetic=\"no\" class=\"ha-creative-btn-wrap\">\n\t\t\t<a class=\"ha-creative-btn ha-stl--hermosa ha-eft--bloom\" href=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-49-53.pdf\" target=\"_blank\"><div><\/div><span>Download article<\/span><\/a>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb4126d jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-ha-creative-button happy-addon ha-creative-button\" data-id=\"eb4126d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-creative-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-magnetic=\"no\" class=\"ha-creative-btn-wrap\">\n\t\t\t<a class=\"ha-creative-btn ha-stl--hermosa ha-eft--bloom\" href=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/certificate-120-11.pdf\" target=\"_blank\"><div><\/div><span>Download certificate<\/span><\/a>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7c3667e jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-ha-creative-button happy-addon ha-creative-button\" data-id=\"7c3667e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-creative-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-magnetic=\"no\" class=\"ha-creative-btn-wrap\">\n\t\t\t<a class=\"ha-creative-btn ha-stl--hermosa ha-eft--bloom\" href=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120.pdf\" target=\"_blank\"><div><\/div><span>\u0421\u043a\u0430\u0447\u0430\u0442\u044c \u043f\u043e\u043b\u043d\u044b\u0439 \u0432\u044b\u043f\u0443\u0441\u043a<\/span><\/a>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32f37a3 elementor-position-left elementor-vertical-align-top jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image-box\" data-id=\"32f37a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"471\" height=\"209\" data-src=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/doi-a.png\" class=\"attachment-full size-full wp-image-850 lazyload\" alt=\"\" data-srcset=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/doi-a.png 471w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/doi-a-300x133.png 300w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/doi-a-18x8.png 18w\" data-sizes=\"(max-width: 471px) 100vw, 471px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 471px; --smush-placeholder-aspect-ratio: 471\/209;\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\"><a href=\"https:\/\/doi.org\/10.5281\/zenodo.10138134\" target=\"_blank\">https:\/\/doi.org\/10.5281\/zenodo.10138134<\/a>\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee4bc4e elementor-position-left elementor-vertical-align-top jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image-box\" data-id=\"ee4bc4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"2000\" height=\"747\" data-src=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/scholar.png\" class=\"attachment-full size-full wp-image-852 lazyload\" alt=\"\" data-srcset=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/scholar.png 2000w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/scholar-300x112.png 300w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/scholar-1024x382.png 1024w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/scholar-768x287.png 768w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/scholar-1536x574.png 1536w, https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/scholar-18x7.png 18w\" data-sizes=\"(max-width: 2000px) 100vw, 2000px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000\/747;\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\"><a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=ru&amp;user=8HVJjYUAAAAJ&amp;sortby=pubdate&amp;authuser=3&amp;citation_for_view=8HVJjYUAAAAJ:KmkpU35IWjAC\" target=\"_blank\">https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=ru&amp;user=8HVJjYUAAAAJ&amp;sortby=pubdate&amp;authuser=3&amp;citation_for_view=8HVJjYUAAAAJ:KmkpU35IWjAC<\/a>\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-48c31e0 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-shortcode\" data-id=\"48c31e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div class=\"heateor_sss_sharing_container heateor_sss_horizontal_sharing\" data-heateor-ss-offset=\"0\" data-heateor-sss-href='https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/'><div class=\"heateor_sss_sharing_ul\"><a aria-label=\"Facebook\" class=\"heateor_sss_facebook\" href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Facebook\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg\" style=\"background-color:#0765FE;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"0 0 32 32\"><path fill=\"#fff\" d=\"M28 16c0-6.627-5.373-12-12-12S4 9.373 4 16c0 5.628 3.875 10.35 9.101 11.647v-7.98h-2.474V16H13.1v-1.58c0-4.085 1.849-5.978 5.859-5.978.76 0 2.072.15 2.608.298v3.325c-.283-.03-.775-.045-1.386-.045-1.967 0-2.728.745-2.728 2.683V16h3.92l-.673 3.667h-3.247v8.245C23.395 27.195 28 22.135 28 16Z\"><\/path><\/svg><\/span><\/a><a aria-label=\"X\" class=\"heateor_sss_button_x\" href=\"https:\/\/twitter.com\/intent\/tweet?text=Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS&url=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"X\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_x\" style=\"background-color:#2a2a2a;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg width=\"100%\" height=\"100%\" style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 32 32\"><path fill=\"#fff\" d=\"M21.751 7h3.067l-6.7 7.658L26 25.078h-6.172l-4.833-6.32-5.531 6.32h-3.07l7.167-8.19L6 7h6.328l4.37 5.777L21.75 7Zm-1.076 16.242h1.7L11.404 8.74H9.58l11.094 14.503Z\"><\/path><\/svg><\/span><\/a><a aria-label=\"Twitter\" class=\"heateor_sss_button_twitter\" href=\"https:\/\/twitter.com\/intent\/tweet?text=Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS&url=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Twitter\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_twitter\" style=\"background-color:#55acee;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"-4 -4 39 39\"><path d=\"M28 8.557a9.913 9.913 0 0 1-2.828.775 4.93 4.93 0 0 0 2.166-2.725 9.738 9.738 0 0 1-3.13 1.194 4.92 4.92 0 0 0-3.593-1.55 4.924 4.924 0 0 0-4.794 6.049c-4.09-.21-7.72-2.17-10.15-5.15a4.942 4.942 0 0 0-.665 2.477c0 1.71.87 3.214 2.19 4.1a4.968 4.968 0 0 1-2.23-.616v.06c0 2.39 1.7 4.38 3.952 4.83-.414.115-.85.174-1.297.174-.318 0-.626-.03-.928-.086a4.935 4.935 0 0 0 4.6 3.42 9.893 9.893 0 0 1-6.114 2.107c-.398 0-.79-.023-1.175-.068a13.953 13.953 0 0 0 7.55 2.213c9.056 0 14.01-7.507 14.01-14.013 0-.213-.005-.426-.015-.637.96-.695 1.795-1.56 2.455-2.55z\" fill=\"#fff\"><\/path><\/svg><\/span><\/a><a aria-label=\"Linkedin\" class=\"heateor_sss_button_linkedin\" href=\"https:\/\/www.linkedin.com\/sharing\/share-offsite\/?url=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Linkedin\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_linkedin\" style=\"background-color:#0077b5;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"0 0 32 32\"><path d=\"M6.227 12.61h4.19v13.48h-4.19V12.61zm2.095-6.7a2.43 2.43 0 0 1 0 4.86c-1.344 0-2.428-1.09-2.428-2.43s1.084-2.43 2.428-2.43m4.72 6.7h4.02v1.84h.058c.56-1.058 1.927-2.176 3.965-2.176 4.238 0 5.02 2.792 5.02 6.42v7.395h-4.183v-6.56c0-1.564-.03-3.574-2.178-3.574-2.18 0-2.514 1.7-2.514 3.46v6.668h-4.187V12.61z\" fill=\"#fff\"><\/path><\/svg><\/span><\/a><a aria-label=\"Mail.ru\" class=\"heateor_sss_button_mail_ru\" href=\"https:\/\/connect.mail.ru\/share?share_url=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Mail.Ru\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_mail_ru\" style=\"background-color:#356fac;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"0 0 32 32\"><path fill=\"#fff\" d=\"M19.975 15.894c-.134-2.542-2.02-4.07-4.3-4.07h-.086c-2.63 0-4.09 2.068-4.09 4.417 0 2.633 1.765 4.296 4.077 4.296 2.58 0 4.275-1.89 4.4-4.127l-.003-.515zm-4.37-6.346c1.755 0 3.407.776 4.62 1.993v.006c0-.584.395-1.024.94-1.024h.14c.85 0 1.025.808 1.025 1.063l.005 9.08c-.06.595.613.9.988.52 1.457-1.497 3.203-7.702-.907-11.295-3.83-3.352-8.967-2.8-11.7-.916-2.904 2.003-4.764 6.438-2.958 10.603 1.968 4.543 7.6 5.896 10.947 4.546 1.696-.684 2.48 1.607.72 2.355-2.66 1.132-10.066 1.02-13.525-4.972-2.338-4.046-2.212-11.163 3.987-14.85 4.74-2.822 10.99-2.042 14.762 1.895 3.937 4.117 3.705 11.82-.137 14.818-1.742 1.36-4.326.035-4.312-1.947l-.02-.647c-1.21 1.203-2.824 1.905-4.58 1.905-3.475 0-6.53-3.056-6.53-6.528 0-3.508 3.057-6.6 6.533-6.6\"\/><\/svg><\/span><\/a><a aria-label=\"Gmail\" class=\"heateor_sss_button_google_gmail\" href=\"https:\/\/mail.google.com\/mail\/?ui=2&view=cm&fs=1&tf=1&su=Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS&body=Link:https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Google Gmail\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_Google_Gmail\" style=\"background-color:#e5e5e5;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"0 0 32 32\"><path fill=\"#fff\" d=\"M2.902 6.223h26.195v19.554H2.902z\"><\/path><path fill=\"#E14C41\" class=\"heateor_sss_no_fill\" d=\"M2.902 25.777h26.195V6.223H2.902v19.554zm22.44-4.007v3.806H6.955v-3.6h.032l.093-.034 6.9-5.558 2.09 1.77 1.854-1.63 7.42 5.246zm0-.672l-7.027-4.917 7.028-6.09V21.1zm-1.17-14.67l-.947.905c-2.356 2.284-4.693 4.75-7.17 6.876l-.078.06L8.062 6.39l16.11.033zm-10.597 9.61l-6.62 5.294.016-10.914 6.607 5.62\"><\/path><\/svg><\/span><\/a><a aria-label=\"Outlook.com\" class=\"heateor_sss_button_outlook_com\" href=\"https:\/\/mail.live.com\/default.aspx?rru=compose?subject=Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS&body=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F&lc=1033&id=64855&mkt=en-us&cbcxt=mai\" title=\"Outlook.com\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_outlook_com\" style=\"background-color:#0072c6;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg width=\"100%\" height=\"100%\" style=\"display:block;border-radius:999px;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"-4 -3.5 40 40\"><path fill=\"#fff\" d=\"M19.52 8.29v5.5l1.92 1.208c.053.016.163.016.212 0l8.27-5.574c0-.66-.613-1.134-.962-1.134h-9.44z\"\/><path fill=\"#fff\" d=\"M19.52 15.84l1.755 1.204c.246.183.543 0 .543 0-.297.183 8.104-5.397 8.104-5.397V21.75c0 1.102-.704 1.562-1.496 1.562H19.52V15.84z\"\/><g fill=\"#fff\"><path d=\"M10.445 13.305c-.6 0-1.073.282-1.426.842-.355.56-.53 1.305-.53 2.23 0 .936.175 1.677.53 2.22.347.546.813.82 1.38.82.59 0 1.055-.266 1.4-.795.344-.53.517-1.266.517-2.206 0-.984-.17-1.744-.502-2.288-.333-.55-.79-.823-1.37-.823z\"\/><path d=\"M2.123 5.5v21.51l16.362 3.428V2.33L2.123 5.5zm10.95 14.387c-.693.91-1.594 1.367-2.706 1.367-1.082 0-1.967-.442-2.65-1.324-.68-.88-1.02-2.03-1.02-3.448 0-1.496.343-2.707 1.037-3.63.693-.926 1.614-1.388 2.754-1.388 1.08 0 1.955.438 2.62 1.324.667.885 1 2.05 1 3.495.004 1.496-.345 2.695-1.034 3.604z\"\/><\/g><\/svg><\/span><\/a><a aria-label=\"Skype\" class=\"heateor_sss_button_skype\" href=\"https:\/\/web.skype.com\/share?url=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Skype\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_skype\" style=\"background-color:#00aff0;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"0 0 32 32\"><path fill=\"#fff\" d=\"M27.15 18c-.007.04-.012.084-.02.126l-.04-.24.06.113c.124-.678.19-1.37.19-2.06 0-1.53-.3-3.013-.892-4.41a11.273 11.273 0 0 0-2.43-3.602 11.288 11.288 0 0 0-8.012-3.32c-.72 0-1.443.068-2.146.203h-.005c.04.023.08.04.118.063l-.238-.037c.04-.01.08-.018.12-.026a6.717 6.717 0 0 0-3.146-.787 6.67 6.67 0 0 0-4.748 1.965A6.7 6.7 0 0 0 4 10.738c0 1.14.293 2.262.844 3.253.007-.04.012-.08.02-.12l.04.238-.06-.114c-.112.643-.17 1.3-.17 1.954a11.285 11.285 0 0 0 3.32 8.012c1.04 1.04 2.25 1.86 3.602 2.43 1.397.592 2.882.89 4.412.89.666 0 1.334-.06 1.985-.175-.038-.02-.077-.04-.116-.063l.242.04c-.046.01-.088.015-.13.02a6.68 6.68 0 0 0 3.3.87 6.661 6.661 0 0 0 4.743-1.963A6.666 6.666 0 0 0 28 21.26c0-1.145-.295-2.27-.85-3.264zm-11.098 4.885c-4.027 0-5.828-1.98-5.828-3.463 0-.76.562-1.294 1.336-1.294 1.723 0 1.277 2.474 4.49 2.474 1.647 0 2.556-.893 2.556-1.808 0-.55-.27-1.16-1.355-1.426l-3.58-.895c-2.88-.723-3.405-2.282-3.405-3.748 0-3.043 2.865-4.186 5.556-4.186 2.478 0 5.4 1.37 5.4 3.192 0 .783-.677 1.237-1.45 1.237-1.472 0-1.2-2.035-4.163-2.035-1.47 0-2.285.666-2.285 1.618 0 .95 1.16 1.254 2.17 1.484l2.65.587c2.905.647 3.64 2.342 3.64 3.94 0 2.47-1.895 4.318-5.726 4.318z\"><\/path><\/svg><\/span><\/a><a aria-label=\"Whatsapp\" class=\"heateor_sss_whatsapp\" href=\"https:\/\/api.whatsapp.com\/send?text=Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS%20https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Whatsapp\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg\" style=\"background-color:#55eb4c;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"-6 -5 40 40\"><path class=\"heateor_sss_svg_stroke heateor_sss_no_fill\" stroke=\"#fff\" stroke-width=\"2\" fill=\"none\" d=\"M 11.579798566743314 24.396926207859085 A 10 10 0 1 0 6.808479557110079 20.73576436351046\"><\/path><path d=\"M 7 19 l -1 6 l 6 -1\" class=\"heateor_sss_no_fill heateor_sss_svg_stroke\" stroke=\"#fff\" stroke-width=\"2\" fill=\"none\"><\/path><path d=\"M 10 10 q -1 8 8 11 c 5 -1 0 -6 -1 -3 q -4 -3 -5 -5 c 4 -2 -1 -5 -1 -4\" fill=\"#fff\"><\/path><\/svg><\/span><\/a><a aria-label=\"Viber\" class=\"heateor_sss_button_viber\" href=\"viber:\/\/forward?text=Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS%20https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F\" title=\"Viber\" rel=\"nofollow noopener\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_viber\" style=\"background-color:#8b628f;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"0 0 32 32\"><path d=\"M22.57 27.22a7.39 7.39 0 0 1-1.14-.32 29 29 0 0 1-16-16.12c-1-2.55 0-4.7 2.66-5.58a2 2 0 0 1 1.39 0c1.12.41 3.94 4.3 4 5.46a2 2 0 0 1-1.16 1.78 2 2 0 0 0-.66 2.84A10.3 10.3 0 0 0 17 20.55a1.67 1.67 0 0 0 2.35-.55c1.07-1.62 2.38-1.54 3.82-.54.72.51 1.45 1 2.14 1.55.93.75 2.1 1.37 1.55 2.94a5.21 5.21 0 0 1-4.29 3.27zM17.06 4.79A10.42 10.42 0 0 1 26.79 15c0 .51.18 1.27-.58 1.25s-.54-.78-.6-1.29c-.7-5.52-3.23-8.13-8.71-9-.45-.07-1.15 0-1.11-.57.05-.87.87-.54 1.27-.6z\" fill=\"#fff\" fill-rule=\"evenodd\"><\/path><path d=\"M24.09 14.06c-.05.38.17 1-.45 1.13-.83.13-.67-.64-.75-1.13-.56-3.36-1.74-4.59-5.12-5.35-.5-.11-1.27 0-1.15-.8s.82-.48 1.35-.42a6.9 6.9 0 0 1 6.12 6.57z\" fill=\"#fff\" fill-rule=\"evenodd\"><\/path><path d=\"M21.52 13.45c0 .43 0 .87-.53.93s-.6-.26-.64-.64a2.47 2.47 0 0 0-2.26-2.43c-.42-.07-.82-.2-.63-.76.13-.38.47-.41.83-.42a3.66 3.66 0 0 1 3.23 3.32z\" fill=\"#fff\" fill-rule=\"evenodd\"><\/path><\/svg><\/span><\/a><a aria-label=\"Telegram\" class=\"heateor_sss_button_telegram\" href=\"https:\/\/telegram.me\/share\/url?url=https%3A%2F%2Fnor-ijournal.com%2Fru%2F2023%2F11%2F13%2F120-11%2F&text=Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS\" title=\"Telegram\" rel=\"nofollow noopener\" target=\"_blank\" style=\"font-size:32px!important;box-shadow:none;display:inline-block;vertical-align:middle\"><span class=\"heateor_sss_svg heateor_sss_s__default heateor_sss_s_telegram\" style=\"background-color:#3da5f1;width:35px;height:35px;border-radius:999px;display:inline-block;opacity:1;float:left;font-size:32px;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box\"><svg style=\"display:block;border-radius:999px;\" focusable=\"false\" aria-hidden=\"true\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"100%\" height=\"100%\" viewbox=\"0 0 32 32\"><path fill=\"#fff\" d=\"M25.515 6.896L6.027 14.41c-1.33.534-1.322 1.276-.243 1.606l5 1.56 1.72 5.66c.226.625.115.873.77.873.506 0 .73-.235 1.012-.51l2.43-2.363 5.056 3.734c.93.514 1.602.25 1.834-.863l3.32-15.638c.338-1.363-.52-1.98-1.41-1.577z\"><\/path><\/svg><\/span><\/a><a class=\"heateor_sss_more\" aria-label=\"More\" title=\"More\" rel=\"nofollow noopener\" style=\"font-size: 32px!important;border:0;box-shadow:none;display:inline-block!important;font-size:16px;padding:0 4px;vertical-align: middle;display:inline;\" href=\"https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/\" onclick=\"event.preventDefault()\"><span class=\"heateor_sss_svg\" style=\"background-color:#ee8e2d;width:35px;height:35px;border-radius:999px;display:inline-block!important;opacity:1;float:left;font-size:32px!important;box-shadow:none;display:inline-block;font-size:16px;padding:0 4px;vertical-align:middle;display:inline;background-repeat:repeat;overflow:hidden;padding:0;cursor:pointer;box-sizing:content-box;\" onclick=\"heateorSssMoreSharingPopup(this, 'https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/', 'Novruzova%20M.%2C%20Talibova%20J.%2C%20Gasimova%20M.%2C%20Muradova%20S.%2C%20Suleymanova%20T.%20-%20GENE%20THERAPY%20IN%20MUCOVISCIDOSIS', '' )\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" viewbox=\"-.3 0 32 32\" version=\"1.1\" width=\"100%\" height=\"100%\" style=\"display:block;border-radius:999px;\" xml:space=\"preserve\"><g><path fill=\"#fff\" d=\"M18 14V8h-4v6H8v4h6v6h4v-6h6v-4h-6z\" fill-rule=\"evenodd\"><\/path><\/g><\/svg><\/span><\/a><\/div><div class=\"heateorSssClear\"><\/div><\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>GENE THERAPY IN MUCOVISCIDOSIS Novruzova M.Doctor of Philosophy in Biology, associate professor Talibova J.Doctor of Philosophy in Medicine, senior lecturer Gasimova M.assistant Muradova S.Doctor of Philosophy in Biology, senior lecturer Suleymanova T.Doctor of Philosophy in Biology, senior lecturerDepartment of Medical Microbiology and Immunology, Azerbaijan Medical UniversityAzerbaijan, Baku AbstractThe article describes the advantage of the CRISPR-Cas 9 gene editing method for the treatment of cystic fibrosis. This method uses plasmids that contain CRISPR-Cas 9 components in the form of DNA, a nuclease expression cassette, and a bay RNA cassette. The advantage of the method is that no matter how CRISPR-Cas 9 is delivered to the cell, it immediately removes some gene fragment or replaces it. And this change remains forever in the cell, and in the descendant of this cell, we hope that this method of treatment will reduce the number of deaths in cystic fibrosis. Keywords: cystic fibrosis, CRISPR-CAS-9, gene fragment, cell, mitochondria. Download article Download certificate Download full issue https:\/\/doi.org\/10.5281\/zenodo.10138134 https:\/\/scholar.google.com\/citations?view_op=view_citation&#038;hl=ru&#038;user=8HVJjYUAAAAJ&#038;sortby=pubdate&#038;authuser=3&#038;citation_for_view=8HVJjYUAAAAJ:KmkpU35IWjAC<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[35],"class_list":["post-1541","post","type-post","status-publish","format-standard","hentry","category-50","tag-meds"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. - GENE THERAPY IN MUCOVISCIDOSIS<\/title>\n<meta name=\"description\" content=\"Methods for filtering the high-frequency component of an image were studied in the work. Based on the simulation results, it was found that a high-pass filter copes with this task most effec-tively: butterworth filter, which can quickly perform processing, and after its application the image retains a large informative component. Ideal and Gaussian high-frequency filters also showed ac-ceptable results; they are only slightly inferior in performance and preservation of the information content of image elements. Difference filters turned out to be less effective, showing the longest processing time, and after their application a large amount of useful information can be lost.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/\" \/>\n<meta property=\"og:locale\" content=\"ru_RU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. - GENE THERAPY IN MUCOVISCIDOSIS\" \/>\n<meta property=\"og:description\" content=\"Methods for filtering the high-frequency component of an image were studied in the work. Based on the simulation results, it was found that a high-pass filter copes with this task most effec-tively: butterworth filter, which can quickly perform processing, and after its application the image retains a large informative component. Ideal and Gaussian high-frequency filters also showed ac-ceptable results; they are only slightly inferior in performance and preservation of the information content of image elements. Difference filters turned out to be less effective, showing the longest processing time, and after their application a large amount of useful information can be lost.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/\" \/>\n<meta property=\"og:site_name\" content=\"NJD-iscience\" \/>\n<meta property=\"article:published_time\" content=\"2023-11-13T09:11:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-21T16:08:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg\" \/>\n<meta name=\"author\" content=\"NJD-iScience\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u041d\u0430\u043f\u0438\u0441\u0430\u043d\u043e \u0430\u0432\u0442\u043e\u0440\u043e\u043c\" \/>\n\t<meta name=\"twitter:data1\" content=\"NJD-iScience\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u041f\u0440\u0438\u043c\u0435\u0440\u043d\u043e\u0435 \u0432\u0440\u0435\u043c\u044f \u0434\u043b\u044f \u0447\u0442\u0435\u043d\u0438\u044f\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 \u043c\u0438\u043d\u0443\u0442\u044b\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/\"},\"author\":{\"name\":\"NJD-iScience\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#\\\/schema\\\/person\\\/2698fc6ff8f5eea1b3f20b14a145899c\"},\"headline\":\"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. &#8211; GENE THERAPY IN MUCOVISCIDOSIS\",\"datePublished\":\"2023-11-13T09:11:09+00:00\",\"dateModified\":\"2023-11-21T16:08:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/\"},\"wordCount\":209,\"publisher\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nor-ijournal.com\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/NJD_120-723x1024.jpg\",\"keywords\":[\"Medical sicences\"],\"articleSection\":[\"120\"],\"inLanguage\":\"ru-RU\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/\",\"url\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/\",\"name\":\"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. - GENE THERAPY IN MUCOVISCIDOSIS\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nor-ijournal.com\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/NJD_120-723x1024.jpg\",\"datePublished\":\"2023-11-13T09:11:09+00:00\",\"dateModified\":\"2023-11-21T16:08:25+00:00\",\"description\":\"Methods for filtering the high-frequency component of an image were studied in the work. Based on the simulation results, it was found that a high-pass filter copes with this task most effec-tively: butterworth filter, which can quickly perform processing, and after its application the image retains a large informative component. Ideal and Gaussian high-frequency filters also showed ac-ceptable results; they are only slightly inferior in performance and preservation of the information content of image elements. Difference filters turned out to be less effective, showing the longest processing time, and after their application a large amount of useful information can be lost.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/#breadcrumb\"},\"inLanguage\":\"ru-RU\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ru-RU\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/#primaryimage\",\"url\":\"https:\\\/\\\/nor-ijournal.com\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/NJD_120-723x1024.jpg\",\"contentUrl\":\"https:\\\/\\\/nor-ijournal.com\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/NJD_120-723x1024.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/2023\\\/11\\\/13\\\/120-11\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/nor-ijournal.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. &#8211; GENE THERAPY IN MUCOVISCIDOSIS\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#website\",\"url\":\"https:\\\/\\\/nor-ijournal.com\\\/\",\"name\":\"NJD-iscience\",\"description\":\"Norwegian Journal of development of the International Science - ISSN 3453-9875\",\"publisher\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/nor-ijournal.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ru-RU\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#organization\",\"name\":\"NJD-iscience\",\"url\":\"https:\\\/\\\/nor-ijournal.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ru-RU\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/nor-ijournal.com\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/cropped-logo-1.png\",\"contentUrl\":\"https:\\\/\\\/nor-ijournal.com\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/cropped-logo-1.png\",\"width\":1108,\"height\":243,\"caption\":\"NJD-iscience\"},\"image\":{\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/nor-ijournal.com\\\/#\\\/schema\\\/person\\\/2698fc6ff8f5eea1b3f20b14a145899c\",\"name\":\"NJD-iScience\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ru-RU\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/648b5b744e4dce9f9e22218a3cdf47278102a0e31d905d12826b9073f5456643?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/648b5b744e4dce9f9e22218a3cdf47278102a0e31d905d12826b9073f5456643?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/648b5b744e4dce9f9e22218a3cdf47278102a0e31d905d12826b9073f5456643?s=96&d=mm&r=g\",\"caption\":\"NJD-iScience\"},\"sameAs\":[\"https:\\\/\\\/2023.nor-ijournal.com\"],\"url\":\"https:\\\/\\\/nor-ijournal.com\\\/ru\\\/author\\\/ad432mdfin45\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. - GENE THERAPY IN MUCOVISCIDOSIS","description":"Methods for filtering the high-frequency component of an image were studied in the work. Based on the simulation results, it was found that a high-pass filter copes with this task most effec-tively: butterworth filter, which can quickly perform processing, and after its application the image retains a large informative component. Ideal and Gaussian high-frequency filters also showed ac-ceptable results; they are only slightly inferior in performance and preservation of the information content of image elements. Difference filters turned out to be less effective, showing the longest processing time, and after their application a large amount of useful information can be lost.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/","og_locale":"ru_RU","og_type":"article","og_title":"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. - GENE THERAPY IN MUCOVISCIDOSIS","og_description":"Methods for filtering the high-frequency component of an image were studied in the work. Based on the simulation results, it was found that a high-pass filter copes with this task most effec-tively: butterworth filter, which can quickly perform processing, and after its application the image retains a large informative component. Ideal and Gaussian high-frequency filters also showed ac-ceptable results; they are only slightly inferior in performance and preservation of the information content of image elements. Difference filters turned out to be less effective, showing the longest processing time, and after their application a large amount of useful information can be lost.","og_url":"https:\/\/nor-ijournal.com\/ru\/2023\/11\/13\/120-11\/","og_site_name":"NJD-iscience","article_published_time":"2023-11-13T09:11:09+00:00","article_modified_time":"2023-11-21T16:08:25+00:00","og_image":[{"url":"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg","type":"","width":"","height":""}],"author":"NJD-iScience","twitter_card":"summary_large_image","twitter_misc":{"\u041d\u0430\u043f\u0438\u0441\u0430\u043d\u043e \u0430\u0432\u0442\u043e\u0440\u043e\u043c":"NJD-iScience","\u041f\u0440\u0438\u043c\u0435\u0440\u043d\u043e\u0435 \u0432\u0440\u0435\u043c\u044f \u0434\u043b\u044f \u0447\u0442\u0435\u043d\u0438\u044f":"2 \u043c\u0438\u043d\u0443\u0442\u044b"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/#article","isPartOf":{"@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/"},"author":{"name":"NJD-iScience","@id":"https:\/\/nor-ijournal.com\/#\/schema\/person\/2698fc6ff8f5eea1b3f20b14a145899c"},"headline":"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. &#8211; GENE THERAPY IN MUCOVISCIDOSIS","datePublished":"2023-11-13T09:11:09+00:00","dateModified":"2023-11-21T16:08:25+00:00","mainEntityOfPage":{"@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/"},"wordCount":209,"publisher":{"@id":"https:\/\/nor-ijournal.com\/#organization"},"image":{"@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/#primaryimage"},"thumbnailUrl":"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg","keywords":["Medical sicences"],"articleSection":["120"],"inLanguage":"ru-RU"},{"@type":"WebPage","@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/","url":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/","name":"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. - GENE THERAPY IN MUCOVISCIDOSIS","isPartOf":{"@id":"https:\/\/nor-ijournal.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/#primaryimage"},"image":{"@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/#primaryimage"},"thumbnailUrl":"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg","datePublished":"2023-11-13T09:11:09+00:00","dateModified":"2023-11-21T16:08:25+00:00","description":"Methods for filtering the high-frequency component of an image were studied in the work. Based on the simulation results, it was found that a high-pass filter copes with this task most effec-tively: butterworth filter, which can quickly perform processing, and after its application the image retains a large informative component. Ideal and Gaussian high-frequency filters also showed ac-ceptable results; they are only slightly inferior in performance and preservation of the information content of image elements. Difference filters turned out to be less effective, showing the longest processing time, and after their application a large amount of useful information can be lost.","breadcrumb":{"@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/#breadcrumb"},"inLanguage":"ru-RU","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/"]}]},{"@type":"ImageObject","inLanguage":"ru-RU","@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/#primaryimage","url":"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg","contentUrl":"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/11\/NJD_120-723x1024.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/nor-ijournal.com\/2023\/11\/13\/120-11\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/nor-ijournal.com\/"},{"@type":"ListItem","position":2,"name":"Novruzova M., Talibova J., Gasimova M., Muradova S., Suleymanova T. &#8211; GENE THERAPY IN MUCOVISCIDOSIS"}]},{"@type":"WebSite","@id":"https:\/\/nor-ijournal.com\/#website","url":"https:\/\/nor-ijournal.com\/","name":"NJD-iscience","description":"Norwegian Journal of development of the International Science - ISSN 3453-9875","publisher":{"@id":"https:\/\/nor-ijournal.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nor-ijournal.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ru-RU"},{"@type":"Organization","@id":"https:\/\/nor-ijournal.com\/#organization","name":"NJD-iscience","url":"https:\/\/nor-ijournal.com\/","logo":{"@type":"ImageObject","inLanguage":"ru-RU","@id":"https:\/\/nor-ijournal.com\/#\/schema\/logo\/image\/","url":"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/cropped-logo-1.png","contentUrl":"https:\/\/nor-ijournal.com\/wp-content\/uploads\/2023\/09\/cropped-logo-1.png","width":1108,"height":243,"caption":"NJD-iscience"},"image":{"@id":"https:\/\/nor-ijournal.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/nor-ijournal.com\/#\/schema\/person\/2698fc6ff8f5eea1b3f20b14a145899c","name":"NJD-iScience","image":{"@type":"ImageObject","inLanguage":"ru-RU","@id":"https:\/\/secure.gravatar.com\/avatar\/648b5b744e4dce9f9e22218a3cdf47278102a0e31d905d12826b9073f5456643?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/648b5b744e4dce9f9e22218a3cdf47278102a0e31d905d12826b9073f5456643?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/648b5b744e4dce9f9e22218a3cdf47278102a0e31d905d12826b9073f5456643?s=96&d=mm&r=g","caption":"NJD-iScience"},"sameAs":["https:\/\/2023.nor-ijournal.com"],"url":"https:\/\/nor-ijournal.com\/ru\/author\/ad432mdfin45\/"}]}},"_links":{"self":[{"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/posts\/1541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/comments?post=1541"}],"version-history":[{"count":4,"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/posts\/1541\/revisions"}],"predecessor-version":[{"id":1546,"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/posts\/1541\/revisions\/1546"}],"wp:attachment":[{"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/media?parent=1541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/categories?post=1541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nor-ijournal.com\/ru\/wp-json\/wp\/v2\/tags?post=1541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}