{"id":2161,"date":"2023-12-26T12:02:42","date_gmt":"2023-12-26T09:02:42","guid":{"rendered":"https:\/\/nor-ijournal.com\/?p=2161"},"modified":"2024-01-08T14:16:08","modified_gmt":"2024-01-08T11:16:08","slug":"123-2","status":"publish","type":"post","link":"https:\/\/nor-ijournal.com\/ru\/2023\/12\/26\/123-2\/","title":{"rendered":"Mutalipov A., Karimjonov H., Zaynabiddinov \u0410., Usmanov P., Omonturdiev S., Rakhimov R. &#8211; DETERMINATION OF THE RELAXANT EFFECT OF SOME HYDROLYZABLE TANNINS ISOLATED FROM THE PLANT SPECIES E. SANESCENS (L.)"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"2161\" class=\"elementor elementor-2161\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t<div class=\"has_eae_slider elementor-element elementor-element-174423c e-flex e-con-boxed jltma-glass-effect-no wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-eae-slider=\"52967\" data-id=\"174423c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"has_eae_slider elementor-element elementor-element-e289846 e-con-full e-flex jltma-glass-effect-no wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-eae-slider=\"84199\" data-id=\"e289846\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b5a0a35 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"b5a0a35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">DETERMINATION OF THE RELAXANT EFFECT OF SOME HYDROLYZABLE TANNINS ISOLATED FROM THE PLANT SPECIES E. SANESCENS (L.)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-863f119 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"863f119\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: right;\"><strong>Mutalipov A<\/strong><strong>.<br \/><\/strong><em>Andijan State University<br \/><\/em><strong>Karimjonov H<\/strong><strong>.<br \/><\/strong><em>Andijan State University<br \/><\/em><strong>Zaynabiddinov \u0410<\/strong><strong>.<br \/><\/strong><em>Andijan Institute of Economics and Construction<br \/><\/em><strong>Usmanov P<\/strong><strong>.<br \/><\/strong><em>Head of the Cell Biophysics Laboratory of the Institute of Biophysics and Biochemistry under UzMU<br \/><\/em><strong>Omonturdiev S<\/strong><strong>.<br \/><\/strong><em>Institute of Bioorganic Chemistry of the Russian Academy of Sciences<br \/><\/em><strong>Rakhimov R<\/strong><strong>.<br \/><\/strong><em>Institute of Bioorganic Chemistry of the Russian Academy of Sciences<\/em><\/p><p><strong>Abstract<br \/><\/strong>In studies, 2,3-di-O-galloyl-\u03b2-D-glucose and 1,2,3,4-tetra-O-galloyl-\u03b2-D-glucose The vasorelaxant effect of &#8211; hydrolyzable tannins on the contractile activity of the rat aortic blood vessel preparation was studied depending on their structure. In our experiments, it was determined that the vasorelaxant effect of hydrolyzable tannins depends on their structure and applied doses, and it was determined that it is related to the blockade of Ca<sup>2+<\/sup> channels of vascular smooth muscle cells and sarcoplasmic reticulum.<\/p><p><strong>\u00a0<\/strong><strong>Keywords:<\/strong> Tannin, blood vessel, relaxant effect, aorta, muscle, Ca<sup>2+<\/sup>-channel, dose, relaxation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-206ce67 jltma-glass-effect-no exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-pdfjs_viewer\" data-id=\"206ce67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"pdfjs_viewer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<iframe 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SANESCENS (L.) Mutalipov A.Andijan State UniversityKarimjonov H.Andijan State UniversityZaynabiddinov \u0410.Andijan Institute of Economics and ConstructionUsmanov P.Head of the Cell Biophysics Laboratory of the Institute of Biophysics and Biochemistry under UzMUOmonturdiev S.Institute of Bioorganic Chemistry of the Russian Academy of SciencesRakhimov R.Institute of Bioorganic Chemistry of the Russian Academy of Sciences AbstractIn studies, 2,3-di-O-galloyl-\u03b2-D-glucose and 1,2,3,4-tetra-O-galloyl-\u03b2-D-glucose The vasorelaxant effect of &#8211; hydrolyzable tannins on the contractile activity of the rat aortic blood vessel preparation was studied depending on their structure. In our experiments, it was determined that the vasorelaxant effect of hydrolyzable tannins depends on their structure and applied doses, and it was determined that it is related to the blockade of Ca2+ channels of vascular smooth muscle cells and sarcoplasmic reticulum. \u00a0Keywords: Tannin, blood vessel, relaxant effect, aorta, muscle, Ca2+-channel, dose, relaxation. 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