Talibova J.
Doctor of Philosophy in Medicine, Senior lecturer
Novruzova M.
Doctor of Philosophy in Biology, Associate Professor
Bakhishova Y.
Doctor of Philosophy in Biology, Senior lecturer
Gasimova M.
Assistant
Suleymanova T.
Doctor of Philosophy in Biology, Senior lecturer
Mansurova H.
Doctor of Philosophy in Medicine, Senior lecturer
Azerbaijan Medical University, Department of Medical microbiology and Immunology

Abstract
To increase the effectiveness of the treatment of chronic sinusitis, a 1% solution of Dioxidin was used in the form of inhalation. In parallel, the second group of patients received oral antibiotics. Edema and hyperemia decreased in patients of both groups 20 days after treatment, however, after inhalation with Dioxidin the indicators of these symptoms were slightly higher.

Keywords: chronic sinusitis, 1% Dioxidin solution, inhalations, rhinitis symptoms, nasal congestion, nasal microflora.

Mammadova S.
Doctor of Philosophy in Medicine
Arkhmammadova G.
Department of Orthopedic Dentistry.Assistent
Hasanova V.
Department of Orthopedic Dentistry assistant
Azerbaijan Medical University,
Baku, Azerbaijan

Abstract
It is known that the oral cavity is a unique ecological system, closely connected with the internal environment of the body and its external environment. The high incidence of damage to the oral cavity is largely due to the peculiarities of its structure and function, constant contact with the external environment, the presence of microflora, and a variety of loads [1,2,5,7]. When making a denture, it is necessary to take into account the characteristics of the dental and somatic status, as well as the microecology of the oral cavity of patients [3,4,b,8]. The choice of construction material is carried out based not only on its physicochemical characteristics, but also on the biological effect on the surrounding tissues of the oral cavity. In recent years, there has been a significant increase in the number of diseases of the oral mucosa caused by the use of various dentures.

 Keywords: metal-ceramic bridges, stainless steel alloys, microecology of the oral cavity.

Stoeva D.
PhD, Assistant Professor, Department of Prosthetic Dentistry, Faculty of Dental Medicine, Medical University of Sofia

Abstract
Prosthetic treatment with dental implants was first introduced in the 1970s when the concept of implant osseointegration was formulated. The positive outcomes achieved led to their widespread use, and implant therapy became a standard protocol for rehabilitation following partial or complete tooth loss. The development of modern technologies and the creation of new materials have resulted in the evolution of various treatment methods. This article analyzes the fundamental principles of implantological treatment, the advantages and disadvantages of the materials used, as well as the indications for their application.

Keywords: dental implants, prosthetic treatment, dentistry, dental materials, CAD/CAM

Mammadova C.
Lecturer of the Department of Pharmacy and Biochemistry,
Nakhchivan State University

Abstract
This article delves into the multifaceted nature of hypertension, a prevalent cardiovascular disorder characterized by persistently elevated arterial blood pressure. It underscores the significant health risks associated with untreated hypertension, including myocardial infarction, stroke, renal dysfunction, and vision impairment, which collectively can severely degrade quality of life and lead to disability. The pathogenesis of hypertension is explored, highlighting the pivotal roles of vascular tone dysregulation, cardiac rhythm abnormalities, alterations in blood volume and pressure, and imbalances in water-salt homeostasis. A distinction is made between essential arterial hypertension, which lacks a specific organ disease cause, and secondary hypertension, which results from underlying organ or systemic diseases.
Furthermore, the article addresses the symptomatic presentation of hypertension, emphasizing common manifestations such as persistent headaches, facial edema, chest pain, visual disturbances, and tinnitus. The severe implications of a hypertensive crisis are also discussed, noting its sudden onset and potential life-threatening symptoms.
The management strategy for hypertension is outlined, advocating for a progressive approach to normalize blood pressure levels. This includes both non-pharmacological interventions—like lifestyle modifications and dietary adjustments—and pharmacological treatments when necessary. Risk factors contributing to the development of hypertension, including genetic predispositions and lifestyle choices, are examined to provide a comprehensive understanding of its etiology.
Lastly, the article proposes the integration of medicinal plants alongside conventional medications in hypertension management, cautioning about the potential interactions and emphasizing the importance of selecting therapeutic plants compatible with pharmaceutical treatments. This holistic approach aims to offer a more nuanced perspective on hypertension management, blending traditional and modern medical practices for optimal patient care.

Keywords: Hypertension Management, Medicinal Plants, Pharmacological Properties

Kolesinskaya R.
MD, PhD, Associate Professor
S.D. Asfendiyarov Kazakh National Medical University, Ministry of Health
Of the Republic of Kazakhstan, Street Tole bi, 88, Almaty, 050000, Republic of Kazakhstan

Abstract
The research paper outlines findings of the cardiac cycle analysis (heart cycle). The cardiac cycle described in the paper demonstrates activity through curves reflecting pressure changes in the left and right heart cavities during one cardiac cycle. The research revealed that paired chambers are filled synchronically (simultaneously) in structures of each pair– left and right atria, left and right ventricles. The filling mechanisms differ for each pair.

Keywords: adjacent chambers; septal motion; interventricular septum; pressure gradients.

Pankov I.
MD, Professor, Head of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy Ministry of Health of the Russian Federation, Chief Researcher of the Research Department of the RCH of the Ministry of Health of the Republic of Tatarstan
Belyakov V.
Candidate of Medical Sciences, Chief Physician of the City Clinical Hospital No. 16Kazan, Chief freelance expert traumatologist-orthopedist of the Ministry of Health of the Republic of Tatarstan, Associate Professor of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy
Sirazitdinov S.
Head of the Traumatology Department of the consultative polyclinic Republican Clinical Hospital, assistant of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy
Emelin A.
Candidate of Medical Sciences, Associate Professor of the Department of Traumatology, Orthopedics and HEP of the Kazan State Medical University of the Ministry of Health of the Russian Federation, orthopedic traumatologist of the Orthopedics Department No. 2 of the Republican Clinical Hospital

Abstract
The article presents an analysis of the results of treatment of 208 fractures of the knee joint area according to the data of the Center of Traumatology of the Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan for 2000-2023. All patients underwent transosseous osteosynthesis with external fixation devices. The observation periods ranged from 1 year to 18 years. The results were evaluated based on the data of clinical and radiological examination of patients. In the vast majority of cases, positive treatment outcomes have been achieved. Transosseous osteosynthesis with external fixation devices provides accurate reposition and stable fixation of fractures and is the most gentle method of surgical treatment. Transosseous osteosynthesis with external fixation devices is the method of choice for this category of injuries and can be used for various types of fractures of the knee joint area. The article presents an analysis of the results of treatment of 208 fractures of the knee joint area according to the Center of Traumatology of the Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan for 2000-2023. All patients underwent transosseous osteosynthesis with external fixation devices. The observation periods ranged from 1 year to 18 years. The results were evaluated based on the data of clinical and radiological examination of patients. In the vast majority of cases, positive treatment outcomes have been achieved. Transosseous osteosynthesis with external fixation devices provides accurate reposition and stable fixation of fractures and is the most gentle method of surgical treatment. Transosseous osteosynthesis with external fixation devices is the method of choice for this category of injuries and can be used for various types of fractures of the knee joint area.

Keywords: fractures of the knee joint, transosseous osteosynthesis, external fixation apparatus.

Belyakov V.
Candidate of Medical Sciences, Chief Physician of the City Clinical Hospital No. 16Kazan, Chief freelance expert traumatologist-orthopedist of the Ministry of Health of the Republic of Tatarstan, Associate Professor of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy
Pankov I.
MD, Professor, Head of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy Ministry of Health of the Russian Federation, Chief Researcher of the Research Department of the RCH of the Ministry of Health of the Republic of Tatarstan
Sirazitdinov S.
Head of the Traumatology Department of the consultative polyclinic Republican Clinical Hospital, assistant of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy

Abstract
The article presents and substantiates the basic principles of blood ozone oxygenation in the complex therapy of hemorheological disorders in highly traumatic surgical interventions. The mechanism of development of perioperative complications from the blood coagulation system, as well as the relationship of blood rheology with microcirculation features, is shown. The main mechanisms of ozone oxygenation in the treatment of patients with severe osteoarticular pathology are presented.

Keywords: highly traumatic surgical interventions, features of microcirculation, hemorheological disorders, ozone oxygenation of blood.

Byurabekova L.
MBA, DBA program doctoral candidate ALMAU, Kazakhstan

Abstract
The article examines a multidisciplinary approach to pandemic management, especially in the context of the Republic of Kazakhstan, highlighting its significance and potential for improving the healthcare system. International practices are analyzed and specific recommendations are proposed for improving the epidemiological service in the country. The study highlights the importance of integrating knowledge from various scientific disciplines and sectors to effectively respond to epidemiological threats and develop sustainable pandemic management strategies.

Keywords: multidisciplinary approach, pandemic management, epidemiological surveillance, healthcare, Kazakhstan, infectious diseases.

Ismayilova Z.
Lecturer of the Nakhchivan State University
Nakhchivan, Azerbaijan

Abstract
The rose plant, commencing its bloom in May, harbors a wealth of active substances within its aerial parts, rendering it an invaluable asset in the medicinal realm for the treatment of various conditions. Its extracts, both aqueous and alcoholic, are celebrated for their antiseptic and anti-inflammatory properties, proving effective in combating diseases and even serving as a remedial option for colds during the colder seasons. The plant’s significance is further augmented by its rich vitamin A content, making it an essential component of health and wellness regimens. Notably, the substance lycopene, found within the rose plant, has been recognized for its efficacy in managing hypertension and treating malignant tumors, evidencing the plant’s therapeutic versatility. In the domain of cosmetology, rose hips, enriched with carotenoids, find particular favor; alcoholic solutions and creams derived from the plant are esteemed for their unparalleled healing effects on the skin. This summary encapsulates the multifaceted benefits and applications of the rose plant, underscoring its indispensable role in both medical treatments and cosmetic formulations, and highlights its profound impact on health and beauty care.

 Keywords: Medicinal properties of rosehip, Rosehip in cosmetology, Health benefits of lycopene.

Koritarova V.
Phd
Doctor in Department of Anesthesiology and Intensive Care at University Hospital specialized in Obstetrics and Gynecology, ,, Maichin dom’’ Sofia, Bulgaria

Abstract
Recent COVID-19 pandemic has led to worldwide increase in cases of Acute Respiratory Distress Syndrome. Pregnancy is associated with physiological respiratory, cardiovascular and immunological changes, which could lead to development of severe viral pulmonary complications. That cause higher rate of maternal and fetal morbidity and mortality.
Application of non –invasive ventilation strategies for treatment of mild to moderate cases of hypoxic Acute Respiratory Distress Syndrome in pregnant women may improve their condition and decrease cases of endotracheal intubation and invasive mechanical ventilation. More investigations for the most successful method of non-invasive mechanical ventilation in pregnant women are necessary.

Keywords: COVID-19, ARDS, CPAP, BIPAP, HFNC