Lazarov G., Mladenov V. - INCREASED VALUES OF THE E2/T RATIO, TOTAL PROSTATE VOLUME AND LOWER URINARY TRACT SYMPTOMS IN MEN AGED 37 TO 45 YEARS. CROSS-SECTIONAL PILOT CLINICAL STUDY

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Nov, Mon, 2023

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Lazarov G., Mladenov V. – INCREASED VALUES OF THE E2/T RATIO, TOTAL PROSTATE VOLUME AND LOWER URINARY TRACT SYMPTOMS IN MEN AGED 37 TO 45 YEARS. CROSS-SECTIONAL PILOT CLINICAL STUDY

INCREASED VALUES OF THE E2/T RATIO, TOTAL PROSTATE VOLUME AND LOWER URINARY TRACT SYMPTOMS IN MEN AGED 37 TO 45 YEARS. CROSS-SECTIONAL PILOT CLINICAL STUDY

Lazarov G.
MD(corresponding author): Department of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 73 Tzarigradsko shose Blvd., 1113 Sofia; Hospital in Obstetrics and Gynecology “St. Sofia”, Аndrological Office, 2 Mihalaki Tashev Str., 1330 Sofia, Bulgaria
ORCID ID: https://orcid.org/0000-0001-7373-4302

Mladenov V.
Clinic of Urology, Medical University, UMBAL Alexandrovska, “Sv G. Sofijski” Str. №1, 1431 Sofia, Bulgaria²
ORCID iD: https://orcid.org/0000-0002-7409-8085

Abstract
Introduction
We were looking for a relationship between total prostate volume, lower urinary tract symptoms and increased values of the E2/T ratio in young men.
Materials and Methods
We have examined 73 men aged 37 to 45 with lower urinary tract symptoms and increased values of the E2/T ratio. We use an appropriate questionnaire, diagnostic ultrasound and uroflowmetry as methods to evaluate total prostate volume, residual urine, and the maximum urinary flow. We selected a control group of 20 men of similar age without lower urinary tract symptoms.
Results
In the patients with lower urinary tract symptoms, we observed, though within the reference limits, significantly decrease in the level of serum testosterone below average values for a prolonged period and increased values of the E2 and E2/T ratio, compared to those of the control group (p<0.001). We found significant differences between the studied patients and those of the control group in a number of points in the answers to the questions (p<0.001), E2/T ratio (p<0.001), total prostate volume (p<0.001) and the maximum urinary flow (p<0.001).
Conclusion
Our study shows that some young men with lower urinary tract symptoms have some reduction in normal testosterone secretion and an increase in estradiol/testosterone ratio values that are significantly different from the same values in their peers without lower urinary tract symptoms. According to our results, overweight and obesity are important, but not а necessary condition for the occurrence of lower urinary tract symptoms and the increase of total prostate volume.