Kolesinskaya R.
MD, PhD, Associate Professor
S.D. Asfendiyarov Kazakh National Medical University, Ministry of Health
Of the Republic of Kazakhstan, Street Tole bi, 88, Almaty, 050000, Republic of Kazakhstan

Abstract
The research paper outlines findings of the cardiac cycle analysis (heart cycle). The cardiac cycle described in the paper demonstrates activity through curves reflecting pressure changes in the left and right heart cavities during one cardiac cycle. The research revealed that paired chambers are filled synchronically (simultaneously) in structures of each pair– left and right atria, left and right ventricles. The filling mechanisms differ for each pair.

Keywords: adjacent chambers; septal motion; interventricular septum; pressure gradients.

Pankov I.
MD, Professor, Head of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy Ministry of Health of the Russian Federation, Chief Researcher of the Research Department of the RCH of the Ministry of Health of the Republic of Tatarstan
Belyakov V.
Candidate of Medical Sciences, Chief Physician of the City Clinical Hospital No. 16Kazan, Chief freelance expert traumatologist-orthopedist of the Ministry of Health of the Republic of Tatarstan, Associate Professor of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy
Sirazitdinov S.
Head of the Traumatology Department of the consultative polyclinic Republican Clinical Hospital, assistant of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy
Emelin A.
Candidate of Medical Sciences, Associate Professor of the Department of Traumatology, Orthopedics and HEP of the Kazan State Medical University of the Ministry of Health of the Russian Federation, orthopedic traumatologist of the Orthopedics Department No. 2 of the Republican Clinical Hospital

Abstract
The article presents an analysis of the results of treatment of 208 fractures of the knee joint area according to the data of the Center of Traumatology of the Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan for 2000-2023. All patients underwent transosseous osteosynthesis with external fixation devices. The observation periods ranged from 1 year to 18 years. The results were evaluated based on the data of clinical and radiological examination of patients. In the vast majority of cases, positive treatment outcomes have been achieved. Transosseous osteosynthesis with external fixation devices provides accurate reposition and stable fixation of fractures and is the most gentle method of surgical treatment. Transosseous osteosynthesis with external fixation devices is the method of choice for this category of injuries and can be used for various types of fractures of the knee joint area. The article presents an analysis of the results of treatment of 208 fractures of the knee joint area according to the Center of Traumatology of the Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan for 2000-2023. All patients underwent transosseous osteosynthesis with external fixation devices. The observation periods ranged from 1 year to 18 years. The results were evaluated based on the data of clinical and radiological examination of patients. In the vast majority of cases, positive treatment outcomes have been achieved. Transosseous osteosynthesis with external fixation devices provides accurate reposition and stable fixation of fractures and is the most gentle method of surgical treatment. Transosseous osteosynthesis with external fixation devices is the method of choice for this category of injuries and can be used for various types of fractures of the knee joint area.

Keywords: fractures of the knee joint, transosseous osteosynthesis, external fixation apparatus.

Belyakov V.
Candidate of Medical Sciences, Chief Physician of the City Clinical Hospital No. 16Kazan, Chief freelance expert traumatologist-orthopedist of the Ministry of Health of the Republic of Tatarstan, Associate Professor of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy
Pankov I.
MD, Professor, Head of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy Ministry of Health of the Russian Federation, Chief Researcher of the Research Department of the RCH of the Ministry of Health of the Republic of Tatarstan
Sirazitdinov S.
Head of the Traumatology Department of the consultative polyclinic Republican Clinical Hospital, assistant of the Department of Traumatology and Orthopedics of the Kazan State Medical Academy

Abstract
The article presents and substantiates the basic principles of blood ozone oxygenation in the complex therapy of hemorheological disorders in highly traumatic surgical interventions. The mechanism of development of perioperative complications from the blood coagulation system, as well as the relationship of blood rheology with microcirculation features, is shown. The main mechanisms of ozone oxygenation in the treatment of patients with severe osteoarticular pathology are presented.

Keywords: highly traumatic surgical interventions, features of microcirculation, hemorheological disorders, ozone oxygenation of blood.

Byurabekova L.
MBA, DBA program doctoral candidate ALMAU, Kazakhstan

Abstract
The article examines a multidisciplinary approach to pandemic management, especially in the context of the Republic of Kazakhstan, highlighting its significance and potential for improving the healthcare system. International practices are analyzed and specific recommendations are proposed for improving the epidemiological service in the country. The study highlights the importance of integrating knowledge from various scientific disciplines and sectors to effectively respond to epidemiological threats and develop sustainable pandemic management strategies.

Keywords: multidisciplinary approach, pandemic management, epidemiological surveillance, healthcare, Kazakhstan, infectious diseases.

Ismayilova Z.
Lecturer of the Nakhchivan State University
Nakhchivan, Azerbaijan

Abstract
The rose plant, commencing its bloom in May, harbors a wealth of active substances within its aerial parts, rendering it an invaluable asset in the medicinal realm for the treatment of various conditions. Its extracts, both aqueous and alcoholic, are celebrated for their antiseptic and anti-inflammatory properties, proving effective in combating diseases and even serving as a remedial option for colds during the colder seasons. The plant’s significance is further augmented by its rich vitamin A content, making it an essential component of health and wellness regimens. Notably, the substance lycopene, found within the rose plant, has been recognized for its efficacy in managing hypertension and treating malignant tumors, evidencing the plant’s therapeutic versatility. In the domain of cosmetology, rose hips, enriched with carotenoids, find particular favor; alcoholic solutions and creams derived from the plant are esteemed for their unparalleled healing effects on the skin. This summary encapsulates the multifaceted benefits and applications of the rose plant, underscoring its indispensable role in both medical treatments and cosmetic formulations, and highlights its profound impact on health and beauty care.

 Keywords: Medicinal properties of rosehip, Rosehip in cosmetology, Health benefits of lycopene.