Magauiya A.
M.Sc.
Ecomed infertility clinic, Kazakhstan
Zhumadil Kh.
B.Sc.
Dimedus LTD, Kazakhstan
Temirkhan A.
B.Sc.
KazNU, faculty of biology and biotechnology, Kazakhstan
Umorbekova G.
M.Sc.
Ecomed infertility clinic, Kazakhstan
Sadyk T.
B.Sc.
Ecomed infertility clinic, Kazakhstan

Abstract
Importance: Rapid growth in human population is putting a strain on agricultural industry. One of the ways to solving this problem is increasing the yield of farm animals by selecting the sex of the offspring.
Objective: To evaluate the effectiveness, safety and availability of various sperm sex sorting methods. 
Evidence review: PubMed search engine was used tofind published works on sperm sex selection methods in the MEDLINE database.
Findings:Search by key words yielded scientific articles describing many sperm sex sorting methods that make use of distinctive features of X- and Y-chromosome bearing sperm cells.
Conclusion and relevance: Many sperm sex sorting methods have been developed over the last half-century, but only some of them had a high level of reproducibility and proved to be reliable. Our review shows that further studies should be performed to eliminate drawbacks of the current methods and solve global problems in the field of animal husbandry and reproductive medicine.

 Keywords: sperm sex selection, sex chromosomes, MicroSort, TLR7/TLR8, sex-specific proteins